PKA phosphorylates Myosin Binding Protein-C (MyBP-C) and troponin I (TnI) throughout the cardiac myofibril. TnI is definitely the inhibitory ingredient of your trimeric troponin molecule that makes up the Ca2+-switch of the contractile equipment. TnI binds to TnC when Ca2+ is bound to TnC, even though while in the absence of Ca2+, the C-terminus of